Blood test breakthrough could detect motor neurone disease a decade before symptoms

Motor neurone disease affects approximately 5,000 UK adults with median life expectancy of 2-5 years post-diagnosis, causing progressive paralysis and respiratory failure.

For generations, motor neurone disease has arrived as a sudden verdict — symptoms appearing, life expectancy measured in years. Now, researchers at Johns Hopkins University have discovered that the disease has been writing its signature in the blood for nearly a decade before any outward sign emerges. By identifying 33 proteins that form a molecular fingerprint unique to ALS, their test achieves 98 percent accuracy in detection, suggesting that what medicine understood as a rapid illness is in fact a long, silent unfolding — and that the window for intervention may be far wider than anyone had

Blood test breakthrough could detect motor neurone disease a decade before symptoms

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