UV Light Triggers Cell Mutations That Drive Corneal Disease, Study Shows

Fuchs endothelial corneal dystrophy causes progressive visual impairment and corneal edema in affected patients, potentially leading to vision loss.

In the quiet architecture of the human eye, a slow betrayal unfolds: cells meant to keep the cornea clear instead respond to ultraviolet light with a desperate gamble — growing larger, hoarding DNA, buying time — until that very survival strategy turns against them. Researchers publishing in Nature have now traced this arc of adaptation and collapse to a single molecular actor, YAP1, illuminating not just the mechanics of Fuchs endothelial corneal dystrophy but a deeper truth about how the body's protective instincts can become the source of its undoing. The discovery opens a therapeutic door

UV Light Triggers Cell Mutations That Drive Corneal Disease, Study Shows

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