Scientists identify mechanism behind breast cancer recurrence, propose prevention strategy

Patients with ER+ breast cancer face years of uncertainty about recurrence; one patient experienced cancer spread to sternum and spine after initial treatment completion.

For decades, the end of breast cancer treatment has offered only conditional relief — a remission shadowed by the knowledge that dormant cells may yet stir. Researchers at the Institute of Cancer Research in London have now identified the biological mechanism behind this reawakening: an aging lung protein called PDGF-C that signals dormant ER+ cancer cells to grow into secondary tumors. The discovery, published in Nature Cancer, not only explains why recurrence strikes some patients and not others, but points toward an existing drug — imatinib — that may one day help prevent it. In the long hu

Scientists identify mechanism behind breast cancer recurrence, propose prevention strategy

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