European cardiology report links ultra-processed foods to heart disease and early death

High consumption of ultra-processed foods contributes to preventable cardiovascular deaths and disability across European populations.
Even foods with good nutritional profiles can be harmful if highly processed.
A researcher explains why counting nutrients alone is insufficient for preventing heart disease.

Adults consuming the most ultra-processed foods face up to 19% higher heart disease risk and 65% greater cardiovascular death risk compared to low consumers. Ultra-processed foods account for 54-61% of calories in Northern Europe but only 18-25% in Southern Europe, revealing stark regional dietary differences.

  • Adults consuming the most ultra-processed foods face 19% higher heart disease risk and 65% greater cardiovascular death risk
  • Ultra-processed foods account for 61% of calories in the Netherlands, 54% in the UK, versus 18-25% in Southern Europe
  • Report led by Professor Luigina Guasti and colleagues from Italian and European institutions
  • Most cardiovascular studies on ultra-processed foods have been observational, not intervention trials

A major European cardiology report warns that high consumption of ultra-processed foods significantly increases risks of heart disease, irregular heartbeats, and cardiovascular death, urging doctors to counsel patients on reducing UPF intake.

A sweeping new report from Europe's leading cardiologists has arrived with a stark warning: the foods most of us eat without thinking—the packaged snacks, the convenient meals, the products lining supermarket shelves—are quietly driving a surge in heart disease and early death. The European Society of Cardiology and the European Association of Preventive Cardiology have issued a clinical consensus statement documenting what researchers have long suspected but never before crystallized into formal medical guidance: ultra-processed foods are a cardiovascular risk factor that doctors need to take seriously, and patients need to understand.

The numbers are sobering. Adults who consume the highest amounts of ultra-processed foods face a 19 percent greater risk of developing heart disease than those who eat the least. The risk of atrial fibrillation—an irregular heartbeat that can lead to stroke—jumps 13 percent. Most striking: the risk of dying from cardiovascular disease climbs as much as 65 percent. These are not marginal differences. They are the kind of numbers that reshape how a person thinks about their lunch.

The research panel, led by Professor Luigina Guasti of the University of Insubria in Italy, along with colleagues from institutions across Europe, found that ultra-processed foods damage the body through multiple pathways. These industrially manufactured products—engineered to be shelf-stable, convenient, and irresistible—tend to be loaded with sugar, salt, and unhealthy fats. But the harm goes deeper. The additives, the altered structure of the food itself, the way these products are designed to promote overeating: all of it triggers inflammation, disrupts metabolism, and alters the gut microbiome in ways that increase cardiovascular risk. Some foods marketed as healthy options still qualify as ultra-processed, the researchers note, which means a consumer reading a label claiming "low fat" or "high fiber" may still be eating something that raises their heart disease risk.

The consumption patterns across Europe reveal a troubling divide. In the Netherlands, ultra-processed foods account for 61 percent of all calories consumed. In the United Kingdom, it is 54 percent. By contrast, in Spain, Portugal, and Italy—countries with longer traditions of cooking from whole ingredients—the figure drops to between 18 and 25 percent. The difference is not merely cultural. It is epidemiological. The regions eating the most ultra-processed foods are the regions where cardiovascular disease rates are highest.

Yet despite a decade of accumulating research, most national dietary guidelines still focus narrowly on nutrients—fat, protein, carbohydrates, vitamins—rather than addressing the degree to which food has been processed. A person following conventional nutrition advice might hit all the recommended targets for sodium and saturated fat while still consuming a diet that is 60 percent ultra-processed. The researchers argue this is a fundamental gap in how medicine approaches prevention.

The report calls for a shift in clinical practice. Doctors caring for patients with heart disease, or those at risk for it, should now ask specifically about ultra-processed food intake the way they ask about smoking or exercise. Healthcare providers should counsel patients on reducing these foods as part of routine cardiovascular care. The researchers also urge governments to strengthen food labeling, update dietary guidelines to explicitly address processing, and consider regulation to limit the marketing of ultra-processed foods as healthy choices.

Dr. Marialaura Bonaccio, one of the lead authors, emphasizes that the evidence linking ultra-processed foods to heart disease is both consistent and biologically plausible. The mechanism is clear: these foods promote obesity, diabetes, and high blood pressure—all major cardiovascular risk factors. They also trigger the kind of chronic inflammation and metabolic disruption that damages the heart and blood vessels over time. What remains uncertain is whether intervention trials will prove that simply reducing ultra-processed food consumption can reverse these risks. Most studies so far have been observational, showing correlation rather than causation. The researchers call for long-term trials to test whether dietary change actually improves outcomes.

What makes this report significant is not that it reveals something entirely new, but that it formalizes what has been building in the scientific literature and brings it into the clinical mainstream. A cardiologist in Milan or Amsterdam can now cite a consensus statement from their professional society when counseling a patient to cook at home more often, to choose whole foods, to understand that disease prevention is not just about counting nutrients but about the fundamental question of how processed a food is. The report suggests that integrating this awareness into routine medical care could improve patient health without adding significant cost or time. For a healthcare system perpetually stretched thin, that is no small thing.

This evidence has not yet made its way into the advice we give to patients on healthy eating.
— Professor Luigina Guasti, University of Insubria
Disease prevention should not focus solely on nutrients, but also on the degree of food processing.
— Dr. Marialaura Bonaccio, IRCCS NEUROMED
A Conversa do Hearth Outra perspectiva sobre a história
Inventor

Why does the processing itself matter so much? Couldn't you just eat a processed food that happens to have good nutritional numbers?

Model

That's the key insight here. A food can hit all the right targets for fat and sodium and still be engineered in ways that damage your metabolism. The additives, the way the food is structured, the fact that it's designed to make you want more—those things operate independently of the nutrient profile.

Inventor

So a "low-fat" processed snack could still be harmful?

Model

Exactly. The researchers specifically mention that some foods marketed as healthier options still qualify as ultra-processed. The marketing label doesn't change what the food does to your body.

Inventor

Why haven't doctors been asking about this already?

Model

Because the evidence hasn't made it into formal clinical guidance until now. A cardiologist might ask about smoking or exercise, but ultra-processed food consumption hasn't been part of the standard conversation. This report is trying to change that.

Inventor

Is the evidence solid enough to make that change?

Model

It's consistent across large populations, which is compelling. But most studies have been observational—they show correlation, not causation. The researchers are calling for intervention trials to prove that actually reducing these foods improves heart health.

Inventor

What would that look like?

Model

Long-term studies where people reduce ultra-processed foods and researchers measure whether their cardiovascular health actually improves. That's the missing piece right now.

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